Publications

Recent Publications

Vosoughi D, Ulahannan A, Li Q, Huszti E, Chruscinski A, Birriel D, Madu G, Teskey G, Aversa M, Martinu T, Juvet S. Humoral immunity to lung antigens early post-transplant confers risk for chronic lung allograft dysfunction. J Heart Lung Transplant. 2025 Feb 17:S1053-2498(25)01661-4. doi: 10.1016/j.healun.2025.02.1577. Epub ahead of print. PMID: 39971216.

Juvet S, Cypel M. All Cloak and No Dagger? Immunosuppression-free Lung Transplantation by Sustained Knockdown of Major Histocompatibility Complex Expression in the Graft. Transplantation. 2025 Feb 11. doi: 10.1097/TP.0000000000005351. Epub ahead of print. PMID: 39930558.

Levy L, Moshkelgosha S, Huszti E, Wang S, Hunter S, Zhang CYK, Ghany R, Keshavjee S, Singer LG, Tikkanen J, Juvet S, Martinu T. Bronchoalveolar lavage cytokine-based risk stratification of clinically-stable lung transplant recipients with undefined rejection: Further insights from a follow-up investigation. J Heart Lung Transplant. 2024 Nov 19:S1053-2498(24)01967-3. doi: 10.1016/j.healun.2024.11.020. Epub ahead of print. PMID: 39571635.

Renaud-Picard B, Moshkelgosha S, Berra G, Cheung M, Hwang D, Hedley D, Juvet S, Martinu T. Detailed cellular and spatial characterization of chronic lung allograft dysfunction using imaging mass cytometry. J Heart Lung Transplant. 2024 Oct 3:S1053-2498(24)01875-8. doi: 10.1016/j.healun.2024.09.023. Epub ahead of print. PMID: 39368678.

Miyamoto E, Vosoughi D, Wang J, Al-Refaee J, Berra G, Daigneault T, Duong A, Joe B, Moshkelgosha S, Keshavjee S, Tinckam K, Hwang D, Chruscinski A, Juvet S, Martinu T. Local intragraft humoral immune responses in chronic lung allograft dysfunction. J Heart Lung Transplant. 2024 Aug 7:S1053-2498(24)01752-2. doi: 10.1016/j.healun.2024.07.019. Epub ahead of print. PMID: 39097215.

Beber SA, Moshkelgosha S, White M, Zehong G, Cheung M, Hedley D, Levy L, Samuels J, Renaud-Picard B, Hwang D, Martinu T, Juvet S. The CD8+ T cell content of transbronchial biopsies from patients with a first episode of clinically stable grade A1 cellular rejection is associated with future chronic lung allograft dysfunction. J Heart Lung Transplant. 2024 Oct;43(10):1654-1664. doi: 10.1016/j.healun.2024.06.001. Epub 2024 Jun 7. PMID: 38852935.

Renaud-Picard B, Berra G, Hwang D, Huszti E, Miyamoto E, Berry GJ, Pal P, Juvet S, Keshavjee S, Martinu T. Spectrum of chronic lung allograft dysfunction pathology in human lung transplantation. J Heart Lung Transplant. 2024 Oct;43(10):1701-1715. doi: 10.1016/j.healun.2024.04.002. Epub 2024 Apr 23. PMID: 38663465.

Kawashima M, Ma J, Huszti E, Levy L, Berra G, Renaud-Picard B, Takahagi A, Ghany R, Sato M, Keshavjee S, Singer L, Husain S, Kumar D, Tikkanen J, Martinu T. Association between cytomegalovirus viremia and long-term outcomes in lung transplant recipients. Am J Transplant. 2024 Jun;24(6):1057-1069. doi: 10.1016/j.ajt.2024.01.027. Epub 2024 Feb 1. PMID: 38307417.

Ramendra R, Duong A, Zhang CYK, Huszti E, Zhou X, Havlin J, Ghany R, Cypel M, Yeung JC, Keshavjee S, Sage AT, Martinu T. Airway pepsinogen A4 identifies lung transplant recipients with microaspiration and predicts chronic lung allograft dysfunction. J Heart Lung Transplant. 2024 Jun;43(6):973-982. doi: 10.1016/j.healun.2024.01.002. Epub 2024 Jan 10. PMID: 38211836.

Levy L, Moshkelgosha S, Huszti E, Hunter S, Renaud-Picard B, Berra G, Kawashima M, Fernandez-Castillo J, Fuchs E, Dianti M, Ghany R, Keshavjee S, Singer LG, Tikkanen J, Martinu T. Pulmonary epithelial markers in phenotypes of chronic lung allograft dysfunction. J Heart Lung Transplant. 2023 Aug;42(8):1152-1160. doi: 10.1016/j.healun.2023.03.009. Epub 2023 Mar 23. PMID: 36963446.

Watanabe T, Lam C, Oliver J, Oishi H, Teskey G, Beber S, Boonstra K, Mauricio Umaña J, Buhari H, Joe B, Guan Z, Horie M, Keshavjee S, Martinu T, Juvet SC. Donor Batf3 inhibits murine lung allograft rejection and airway fibrosis. Mucosal Immunol. 2023 Apr;16(2):104-120. doi: 10.1016/j.mucimm.2023.02.004. Epub 2023 Feb 25. PMID: 36842540.

Ramendra R, Sage AT, Yeung J, Fernandez-Castillo JC, Cuesta M, Aversa M, Liu M, Cypel M, Keshavjee S, Martinu T. Triaging donor lungs based on a microaspiration signature that predicts adverse recipient outcome. J Heart Lung Transplant. 2023 Apr;42(4):456-465. doi: 10.1016/j.healun.2022.12.024. Epub 2023 Jan 6. PMID: 36710092.

Riddell P, Ma J, Lazarte J, Birriel D, Ulahannan A, Ghany R, Delgado D, Rao V, Keshavjee S, Martinu T, Tikkanen J, Juvet SC. Donor and recipient human leukocyte antigen-G polymorphisms modulate the risk of adverse immunologic events following lung transplantation. Am J Transplant. 2023 Mar;23(3):393-400. doi: 10.1016/j.ajt.2022.12.008. Epub 2023 Jan 4. PMID: 36695689.

Martinu T, Todd JL, Gelman AE, Guerra S, Palmer SM. Club Cell Secretory Protein in Lung Disease: Emerging Concepts and Potential Therapeutics. Annu Rev Med. 2023 Jan 27;74:427-441. doi: 10.1146/annurev-med-042921-123443. Epub 2022 Nov 30. PMID: 36450281; PMCID: PMC10472444.

Zhang CYK, Ahmed M, Huszti E, Levy L, Hunter SE, Boonstra KM, Moshkelgosha S, Sage AT, Azad S, Ghany R, Yeung JC, Crespin OM, Singer LG, Keshavjee S, Martinu T. Utility of bile acids in large airway bronchial wash versus bronchoalveolar lavage as biomarkers of microaspiration in lung transplant recipients: a retrospective cohort study. Respir Res. 2022 Aug 26;23(1):219. doi: 10.1186/s12931-022-02131-5. PMID: 36028826; PMCID: PMC9419323.

Moshkelgosha S, Duong A, Wilson G, Andrews T, Berra G, Renaud-Picard B, Liu M, Keshavjee S, MacParland S, Yeung J, Martinu T, Juvet S. Interferon-stimulated and metallothionein-expressing macrophages are associated with acute and chronic allograft dysfunction after lung transplantation. J Heart Lung Transplant. 2022 Nov;41(11):1556-1569. doi: 10.1016/j.healun.2022.05.005. Epub 2022 May 20. PMID: 35691795.

Berra G, Huszti E, Levy L, Kawashima M, Fuchs E, Renaud-Picard B, Riddell P, Dias O, Rajagopala S, Ulahannan A, Ghany R, Singer LG, Tikkanen J, Martinu T. Phenotyping CLAD after single lung transplant: Limits and prognostic assessment of the 2019 ISHLT classification system. J Heart Lung Transplant. 2022 May;41(5):599-607. doi: 10.1016/j.healun.2022.01.015. Epub 2022 Jan 23. PMID: 35351385.

Watanabe T, Juvet SC, Boonstra K, Guan Z, Joe B, Teskey G, Keshavjee S, Martinu T. Recipient bone marrow-derived IL-17 receptor A-positive cells drive allograft fibrosis in a mouse intrapulmonary tracheal transplantation model. Transpl Immunol. 2021 Dec;69:101467. doi: 10.1016/j.trim.2021.101467. Epub 2021 Sep 20. PMID: 34547417.

Miyamoto E, Takahagi A, Ohsumi A, Martinu T, Hwang D, Boonstra KM, Joe B, Umana JM, Bei KF, Vosoughi D, Liu M, Cypel M, Keshavjee S, Juvet SC. Ex vivo delivery of regulatory T-cells for control of alloimmune priming in the donor lung. Eur Respir J. 2022 Apr 14;59(4):2100798. doi: 10.1183/13993003.00798-2021. PMID: 34475226.

Darley DR, Ma J, Huszti E, Ghany R, Hutcheon M, Chow CW, Tikkanen J, Keshavjee S, Singer LG, Martinu T. Diffusing capacity of the lung for carbon monoxide: association with long-term outcomes after lung transplantation in a 20-year longitudinal study. Eur Respir J. 2022 Jan 27;59(1):2003639. doi: 10.1183/13993003.03639-2020. PMID: 34172463.

Riddell P, Vasudevan-Nampoothiri R, Ma J, Singer LG, Lipton JH, Juvet SC. Lung transplantation for late-onset non-infectious chronic pulmonary complications of allogenic hematopoietic stem cell transplant. Respir Res. 2021 Apr 7;22(1):101. doi: 10.1186/s12931-021-01699-8. PMID: 33827576; PMCID: PMC8025894.

Riddell P, Moshkelgosha S, Levy L, Chang N, Pal P, Halloran K, Halloran P, Parkes M, Singer LG, Keshavjee S, Martinu T, Juvet SC. IL-6 receptor blockade for allograft dysfunction after lung transplantation in a patient with COPA syndrome. Clin Transl Immunology. 2021 Jan 28;10(2):e1243. doi: 10.1002/cti2.1243. PMID: 33537146; PMCID: PMC7843402.

Martinu T, Koutsokera A, Benden C, Cantu E, Chambers D, Cypel M, Edelman J, Emtiazjoo A, Fisher AJ, Greenland JR, Hayes D Jr, Hwang D, Keller BC, Lease ED, Perch M, Sato M, Todd JL, Verleden S, von der Thüsen J, Weigt SS, Keshavjee S; bronchoalveolar lavage standardization workgroup. International Society for Heart and Lung Transplantation consensus statement for the standardization of bronchoalveolar lavage in lung transplantation. J Heart Lung Transplant. 2020 Nov;39(11):1171-1190. doi: 10.1016/j.healun.2020.07.006. Epub 2020 Jul 15. PMID: 32773322; PMCID: PMC7361106.

Zhang CYK, Ahmed M, Huszti E, Levy L, Hunter SE, Boonstra KM, Moshkelgosha S, Sage AT, Azad S, Zamel R, Ghany R, Yeung JC, Crespin OM, Frankel C, Budev M, Shah P, Reynolds JM, Snyder LD, Belperio JA, Singer LG, Weigt SS, Todd JL, Palmer SM, Keshavjee S, Martinu T; CTOT-20 investigators. Bronchoalveolar bile acid and inflammatory markers to identify high-risk lung transplant recipients with reflux and microaspiration. J Heart Lung Transplant. 2020 Sep;39(9):934-944. doi: 10.1016/j.healun.2020.05.006. Epub 2020 May 19. PMID: 32487471; PMCID: PMC7483994.

Lazarte J, Ma J, Martinu T, Levy L, Klement W, White M, Pelling J, Guan Z, Azad S, Tikkanen J, Rao V, Tomlinson G, Delgado D, Keshavjee S, Juvet SC. Donor human leukocyte antigen-G single nucleotide polymorphisms are associated with post-lung transplant mortality. Eur Respir J. 2019 Aug 15;54(2):1802126. doi: 10.1183/13993003.02126-2018. PMID: 31164432.

Levy L, Juvet SC, Boonstra K, Singer LG, Azad S, Joe B, Cypel M, Keshavjee S, Martinu T. Sequential broncho-alveolar lavages reflect distinct pulmonary compartments: clinical and research implications in lung transplantation. Respir Res. 2018 May 25;19(1):102. doi: 10.1186/s12931-018-0786-z. PMID: 29801490; PMCID: PMC5970521.

Juvet SC, Moshkelgosha S, Sanderson S, Hester J, Wood KJ, Bushell A. Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry. J Vis Exp. 2017 Apr 19;(122):55283. doi: 10.3791/55283. PMID: 28448002; PMCID: PMC5408926.

Juvet SC, Thomson CW, Kim EY, Joe B, Adeyi O, Zhang L. FcRγ promotes T cell apoptosis in Fas-deficient mice. J Autoimmun. 2013 May;42:80-93. doi: 10.1016/j.jaut.2012.12.002. Epub 2013 Jan 10. PMID: 23313147.

Martinu T, Pavlisko EN, Chen DF, Palmer SM. Acute allograft rejection: cellular and humoral processes. Clin Chest Med. 2011 Jun;32(2):295-310. doi: 10.1016/j.ccm.2011.02.008. Epub 2011 Mar 25. PMID: 21511091; PMCID: PMC3089893.

Martinu T, Kinnier CV, Gowdy KM, Kelly FL, Snyder LD, Jiang D, Foster WM, Garantziotis S, Belperio JA, Noble PW, Palmer SM. Innate immune activation potentiates alloimmune lung disease independent of chemokine (C-X-C motif) receptor 3. J Heart Lung Transplant. 2011 Jun;30(6):717-25. doi: 10.1016/j.healun.2011.01.711. Epub 2011 Mar 27. PMID: 21444213; PMCID: PMC3091946.

Martinu T, Babyak MA, O'Connell CF, Carney RM, Trulock EP, Davis RD, Blumenthal JA, Palmer SM; INSPIRE Investigators. Baseline 6-min walk distance predicts survival in lung transplant candidates. Am J Transplant. 2008 Jul;8(7):1498-505. doi: 10.1111/j.1600-6143.2008.02264.x. PMID: 18510641; PMCID: PMC2714545.

Martinu T, Clay AS. A 50-year-old woman with bilateral vocal cord paralysis and hilar mass. Chest. 2005 Aug;128(2):1028-31. doi: 10.1378/chest.128.2.1028. PMID: 16100203.