Meet the Principal Investigators
The CLAD Team was established in 2015 through the partnership of Dr. Stephen Juvet and Dr. Tereza Martinu, uniting their expertise to address the complexities of CLAD. As part of the Latner Thoracic Research Laboratories, within the Toronto Lung Transplant Program and University Health Network, their research spans affiliations with the Institute of Medical Science, Department of Immunology, and Department of Laboratory Medicine and Pathobiology at the University of Toronto. By employing a multidisciplinary approach and advanced methodologies, they aim to transform outcomes for lung transplant recipients worldwide.
Stephen Juvet - MD, PhD, FRCPC
I am a clinician-scientist and respirologist with the Toronto Lung Transplant Program. I am a graduate of the University of Toronto Faculty of Medicine (MD 2002) and the Institute of Medical Science (PhD 2013). After postdoctoral training in Oxford, UK (2013-2014) I returned to the University Health Network to initiate a fundamental and translational research program in transplantation immunology. My research is focused on mechanisms of chronic rejection and the determinants of immunological tolerance in transplanted lungs and other solid organs. We are using rodent models to examine how chronic lung allograft rejection is exacerbated by inflammation in the lung, and to apply novel therapeutic strategies to transplanted organs prior to surgical implantation in the recipient. We also have access to an extensive biobank of human specimens for translational studies. Projects involving organ-specific mechanisms of rejection, tertiary lymphoid structures, and regulatory T cells are ongoing in the lab.
Contact: Stephen.Juvet@uhn.ca
X: stephenjmdphd
Tereza Martinu - MD, MHSc.
I am a lung transplant respirologist and clinician-scientist with the Toronto Lung Transplant Program. I obtained my Medical Degree (2002) from McGill University in Montreal, Canada. I subsequently completed training in Internal and then Pulmonary and Critical Care Medicine (2008) at Duke University, in North Carolina, USA, before joining the Duke Lung Transplant Program. In 2014, I completed research fellowship training in transplant immunology and obtained a Masters in Health Sciences at Duke University. I transitioned to the Toronto program in August 2014. In my clinical time, I care for lung transplant patients and candidates with end-stage lung diseases. In my research time, I study chronic lung allograft dysfunction (CLAD), the main long-term complication of lung transplantation. My team’s research studies focus on immunological and cellular mechanisms of CLAD in humans as well as in animal models. Our goal is to develop improved diagnostic and therapeutic approaches for lung transplant patients with allograft dysfunction.
Contact: Tereza.Martinu@uhn.ca
X: Tereza_Martinu
